Journal article

Control of viremia and prevention of AIDS following immunotherapy of SIV-infected macaques with peptide-pulsed blood

Robert De Rose, Caroline S Fernandez, Miranda Z Smith, C Jane Batten, Sheilajen Alcantara, Vivienne Peut, Erik Rollman, Liyen Loh, Rosemarie D Mason, Kim Wilson, Matthew G Law, Amanda J Handley, Stephen J Kent

PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2008

Abstract

Effective immunotherapies for HIV are needed. Drug therapies are life-long with significant toxicities. Dendritic-cell based immunotherapy approaches are promising but impractical for widespread use. A simple immunotherapy, reinfusing fresh autologous blood cells exposed to overlapping SIV peptides for 1 hour ex vivo, was assessed for the control of SIV(mac251) replication in 36 pigtail macaques. An initial set of four immunizations was administered under antiretroviral cover and a booster set of three immunizations administered 6 months later. Vaccinated animals were randomized to receive Gag peptides alone or peptides spanning all nine SIV proteins. High-level, SIV-specific CD4 and CD8 T-c..

View full abstract