Journal article

Corpus callosum shape alterations in individuals prior to the onset of psychosis

Mark Walterfang, Alison Yung, Amanda G Wood, David C Reutens, Lisa Phillips, Stephen J Wood, Jian Chen, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis



Reductions in the size of the anterior callosum have been described for both first-episode schizophrenia-spectrum psychosis and established schizophrenia, but have not been examined in individuals at ultra-high risk for psychosis (UHR). We compared 100 UHR individuals (27 of whom later developed psychosis) with 38 age-matched control subjects on measures of size and shape of the corpus callosum to determine if changes previously demonstrated in first-episode and established schizophrenia are present in the pre-psychotic phase. Each individual's callosum was extracted from the mid-sagittal slice from T1-weighted magnetic resonance images, and total area, length and curvature of the callosum w..

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Awarded by National Health & Medical Research Council

Awarded by NHMRC Program

Awarded by NHMRC

Funding Acknowledgements

This research was supported by project grants from the National Health & Medical Research Council (NHMRC; grant ID numbers: 970598, 981112), Ian Potter Foundation, Woods Family Trust, an NHMRC Program Grant (350241) and a program grant from the Victorian Health Promotion Foundation. Dr Walterfang was supported by a Stanley Research Centre Grant. Dr A Wood was supported by an NHMRC Clinical Research Training Fellowship (251755). Dr S Wood was supported by an NHMRC Clinical Career Development Award. Professor McGorry was supported by a NARSAD Distinguished Investigator Award. Dr Walterfang takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors had full access to all the data in the study.