Journal article

Leptin in depressed women: Cross-sectional and longitudinal data from an epidemiologic study

Julie A Pasco, Felice N Jacka, Lana J Williams, Margaret J Henry, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2008

Abstract

BACKGROUND: There is conflicting evidence regarding levels of leptin in depression. In this study we aimed to investigate the relationship between serum leptin level and depression in a community sample of women using both cross-sectional and longitudinal data. METHODS: From among 510 women aged 20-78 yr, 83 were identified with a lifetime history of major depressive disorder or dysthymia, ascertained using the Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition (SCID-I/NP). Serum leptin levels were measured by radioimmunoassay. Medication use and lifestyle were self-reported and body mass index (BMI) determined from measures of height and weight. RESULTS: Using..

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