Journal article

Heritability of intraocular pressure: a classical twin study

F Carbonaro, T Andrew, DA Mackey, TD Spector, CJ Hammond

BRITISH JOURNAL OF OPHTHALMOLOGY | B M J PUBLISHING GROUP | Published : 2008

Abstract

AIMS: To estimate the heritability of intraocular pressure (IOP) by performing a classical twin study and to determine whether the use of different instruments influences calculation of eye IOP heritability. METHODS: Twin pairs were recruited to participate from the TwinsUK Adult Twin Registry at St. Thomas' Hospital London. IOP was measured using Goldmann applanation tonometry (GAT). A subset of twins also had their IOP measured using the Ocular Response Analyser (ORA; Reichert, Buffalo, NY) and the Dynamic Contour Tonometer (DCT, Pascal; Swiss Microtechnology AG, Port, Switzerland). We compared the covariance of IOP within monozygotic (MZ) and dizygotic (DZ) pairs using genetic modelling t..

View full abstract