Journal article

Regional brain abnormalities associated with long-term heavy cannabis use

Murat Yuecel, Nadia Solowij, Colleen Respondek, Sarah Whittle, Alex Fornito, Christos Pantelis, Dan I Lubman

ARCHIVES OF GENERAL PSYCHIATRY | AMER MEDICAL ASSOC | Published : 2008

Abstract

CONTEXT: Cannabis is the most widely used illicit drug in the developed world. Despite this, there is a paucity of research examining its long-term effect on the human brain. OBJECTIVE: To determine whether long-term heavy cannabis use is associated with gross anatomical abnormalities in 2 cannabinoid receptor-rich regions of the brain, the hippocampus and the amygdala. DESIGN: Cross-sectional design using high-resolution (3-T) structural magnetic resonance imaging. SETTING: Participants were recruited from the general community and underwent imaging at a hospital research facility. PARTICIPANTS: Fifteen carefully selected long-term (>10 years) and heavy (>5 joints daily) cannabis-using men ..

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