Journal article

AT(1) receptor inhibition prevents astrocyte degeneration and restores vascular growth in oxygen-induced retinopathy

Laura E Downie, Michael J Pianta, Algis J Vingrys, Jennifer L Wilkinson-Berka, Erica L Fletcher

GLIA | WILEY | Published : 2008

Abstract

We investigated the effect of receptor blockade induced by an angiotensin II type-1 receptor antagonist (AT(1)-RB) on glial and vascular changes in oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity (ROP). OIR was induced in Sprague-Dawley rats by exposure to 80% oxygen from postnatal (P) days 0-11, followed by 7 days in room air. Control animals were in room air for the entire duration. One cohort of OIR and control pups received the AT(1)-RB valsartan (40 mg/kg/day intraperitoneal) from P11 to P18. The vascular response was examined immunocytochemically using retinal wholemounts and vertical sections labeled with endothelial (Isolectin-B4) and pericyte (NG2, desmin) ma..

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