The L1-type cell adhesion molecule Neuroglian is necessary for maintenance of sensory axon advance in the Drosophila embryo
Veronica Martin, Eli Mrkusich, Martin C Steinel, Jason Rice, David J Merritt, Paul M Whitington
NEURAL DEVELOPMENT | BMC | Published : 2008
BACKGROUND: Cell adhesion molecules have long been implicated in the regulation of axon growth, but the precise cellular roles played by individual cell adhesion molecules and the molecular basis for their action are still not well understood. We have used the sensory system of the Drosophila embryo to shed light on the mechanism by which the L1-type cell adhesion molecule Neuroglian regulates axon growth. RESULTS: We have found a highly penetrant sensory axon stalling phenotype in neuroglian mutant embryos. Axons stalled at a variety of positions along their normal trajectory, but most commonly in the periphery some distance along the peripheral nerve. All lateral and dorsal cluster sensory..View full abstract
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Awarded by NHMRC
Awarded by ARC Discovery
We thank Michael Hortsch for the gift of UAS-Nrg and UAS-Nrg<SUP>GPI</SUP> lines and Yuh-Nung Jan for 49C4 antibody. All other mutant and transgenic lines were obtained from the Bloomington Stock Center. Financial support was provided by NH&MRC Project Grant 350426 (PMW and DJM) and ARC Discovery Grant DP0558835 (PMW).