Journal article

Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice

Rachel A Davey, Andrew G Turner, Julie F McManus, WS Maria Chiu, Francisca Tjahyono, Alison J Moore, Gerald J Atkins, Paul H Anderson, Cathy Ma, Vaida Glatt, Helen E MacLean, Cristina Vincent, Mary Bouxsein, Howard A Morris, David M Findlay, Frey D Zajac

JOURNAL OF BONE AND MINERAL RESEARCH | WILEY | Published : 2008

Abstract

It is well established that calcitonin is a potent inhibitor of bone resorption; however, a physiological role for calcitonin acting through its cognate receptor, the calcitonin receptor (CTR), has not been identified. Data from previous genetically modified animal models have recognized a possible role for calcitonin and the CTR in controlling bone formation; however, interpretation of these data are complicated, in part because of their mixed genetic background. Therefore, to elucidate the physiological role of the CTR in calcium and bone metabolism, we generated a viable global CTR knockout (KO) mouse model using the Cre/loxP system, in which the CTR is globally deleted by >94% but <100%...

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