Journal article

Evidence of arteriolar narrowing in low-birth-weight children

Paul Mitchell, Gerald Liew, Elena Rochtchina, Jie Jin Wang, Dana Robaei, Ning Cheung, Tien Y Wong

CIRCULATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2008

Abstract

BACKGROUND: Cardiovascular disease may have its origins in utero, but the influence of in utero growth on microvascular structure in children is unknown. We hypothesized that poor in utero growth is associated with narrower arteriolar caliber, which may help explain the established association of low birth weight with hypertension and cardiovascular disease in adulthood. METHODS AND RESULTS: We examined the relation of birth weight and other markers of in utero growth to microvascular caliber in the retina in a population-based study of 1369 6-year-old children in Sydney, Australia (Sydney Childhood Eye Study). Birth weight, birth length, and head circumference were obtained from parental re..

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