Recall and recognition of verbal paired associates in early Alzheimer's disease
GJ Lowndes, MM Saling, D Ames, E Chiu, LM Gonzalez, GR Savage
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY | CAMBRIDGE UNIV PRESS | Published : 2008
The primary impairment in early Alzheimer's disease (AD) is encoding/consolidation, resulting from medial temporal lobe (MTL) pathology. AD patients perform poorly on cued-recall paired associate learning (PAL) tasks, which assess the ability of the MTLs to encode relational memory. Since encoding and retrieval processes are confounded within performance indexes on cued-recall PAL, its specificity for AD is limited. Recognition paradigms tend to show good specificity for AD, and are well tolerated, but are typically less sensitive than recall tasks. Associate-recognition is a novel PAL task requiring a combination of recall and recognition processes. We administered a verbal associate-recogn..View full abstract
For assistance with patient recruitment the authors acknowledge the support of Ms. Jennine Melville, Manager, Cognitive Dementia and Memory Service (CDAMS), Kingston Centre, Southern Health, Victoria. For assistance with statistical analyses the authors acknowledge Dr. Simon Moss. School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton.