Journal article

Recall and recognition of verbal paired associates in early Alzheimer's disease

GJ Lowndes, MM Saling, D Ames, E Chiu, LM Gonzalez, GR Savage

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY | CAMBRIDGE UNIV PRESS | Published : 2008

Abstract

The primary impairment in early Alzheimer's disease (AD) is encoding/consolidation, resulting from medial temporal lobe (MTL) pathology. AD patients perform poorly on cued-recall paired associate learning (PAL) tasks, which assess the ability of the MTLs to encode relational memory. Since encoding and retrieval processes are confounded within performance indexes on cued-recall PAL, its specificity for AD is limited. Recognition paradigms tend to show good specificity for AD, and are well tolerated, but are typically less sensitive than recall tasks. Associate-recognition is a novel PAL task requiring a combination of recall and recognition processes. We administered a verbal associate-recogn..

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