Journal article

The cognitive efffects of modulating the glycine site of the NMDA receptor with high-dose glycine in healthy controls

Colin Palmer, Kathryn A Ellis, Barry V O'Neill, Rodney J Croft, Sumie Leung, Chris Oliver, Keith A Wesnes, Pradeep J Nathan

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | WILEY | Published : 2008

Abstract

N-methyl-D-aspartate (NMDA) receptors play an important role in learning and memory. Targeting the glycine modulatory site of the NMDA receptor has been suggested as a therapeutic strategy to improve cognition, although findings have not been convincing. We used the Cognitive Drug Research computerised assessment system to examine the effects of high-dose glycine on a number of cognitive processes in healthy young subjects. The study was a randomised placebo controlled repeated measures design in which each subject received acute placebo or glycine (0.8 g/kg) orally, with treatment conditions separated by a 5-day washout period. No significant effects of glycine were found on measures of wor..

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University of Melbourne Researchers