The pattern of Fos expression in the spinal dorsal horn following acute noxious mechanical stimulation of bone
Jason J Ivanusic
EUROPEAN JOURNAL OF PAIN | ELSEVIER SCI LTD | Published : 2008
Little is known of the spinal mechanisms that mediate bone nociception. The aim of this study was to determine the pattern of neuronal activation in the spinal dorsal horn following acute noxious mechanical stimulation of bone. This was achieved by examining Fos expression in the spinal dorsal horn following acute, noxious mechanical stimulation of the rat tibia. Noxious mechanical stimuli were applied by bone drilling and raising tibial intra-osseous pressure. Control experiments consisted of surgery to expose the tibia. There was a significant increase in the number of Fos-like immunoreactive (Fos-LI) nuclei in the superficial, ipsilateral dorsal horn of animals in the bone drilling and pr..View full abstract
This study was supported by funding attained from the Faculty of Medicine, University of New South Wales, and the Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne. The author acknowledges the technical assistance of Mr. Peter Carr-Boyd.