Journal article

The pattern of Fos expression in the spinal dorsal horn following acute noxious mechanical stimulation of bone

Jason J Ivanusic

EUROPEAN JOURNAL OF PAIN | ELSEVIER SCI LTD | Published : 2008

Abstract

Little is known of the spinal mechanisms that mediate bone nociception. The aim of this study was to determine the pattern of neuronal activation in the spinal dorsal horn following acute noxious mechanical stimulation of bone. This was achieved by examining Fos expression in the spinal dorsal horn following acute, noxious mechanical stimulation of the rat tibia. Noxious mechanical stimuli were applied by bone drilling and raising tibial intra-osseous pressure. Control experiments consisted of surgery to expose the tibia. There was a significant increase in the number of Fos-like immunoreactive (Fos-LI) nuclei in the superficial, ipsilateral dorsal horn of animals in the bone drilling and pr..

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University of Melbourne Researchers