Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?
Voula Mitsakos, Renwick CJ Dobson, F Grant Pearce, Sean R Devenish, Genevieve L Evans, Benjamin R Burgess, Matthew A Perugini, Juliet A Gerrard, Craig A Hutton
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2008
Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined. The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable.