Journal article

Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infection

Sharon R Lewin, John M Murray, Ajantha Solomon, Fiona Wightman, Paul U Cameron, Damian J Purcell, John J Zaunders, Pat Grey, Mark Bloch, David A Cooper, Anthony D Kelleher, Don Smith

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | LIPPINCOTT WILLIAMS & WILKINS | Published : 2008

Abstract

BACKGROUND: Latently infected resting memory CD4 T cells are thought to be the major reservoir that contributes to rebound viremia after cessation of antiretrovirals (ARVs). Commencing ARVs during primary HIV-1 infection (PHI) may limit the size of the latent pool and lead to improved control of viral replication during structured treatment interruption (STI). METHODS: Individuals with PHI (n = 59) were randomized to receive ARVs with or without hydroxyurea. After STI, a good response was defined as maintenance of HIV-1 RNA <5000 copies/mL for 24 weeks off therapy. In a detailed prospective virologic substudy (n = 19), integrated HIV-1 DNA, total HIV-1 DNA, and cell-associated HIV-1 unsplice..

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