PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins
Hong He, Arthur Shulkes, Graham S Baldwin
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | ELSEVIER | Published : 2008
Beta-catenin regulates cell-cell adhesion by binding to E-cadherin at the cell membrane and, when translocated into the nucleus, mediates signalling by activation of transcription factors such as TCF4. Mutations of the components of the Wnt/beta-catenin pathway are found in many gastrointestinal cancers. Gastrins, including amidated (Gamide) and glycine-extended (Ggly) gastrin(17), stimulate the proliferation of gastrointestinal cancer cells. Gastrins also regulate beta-catenin signalling through multiple pathways which seem to converge on p21-activated kinase 1 (PAK1). In this study, we have investigated the role of PAK1 in the regulation of beta-catenin signalling by gastrins. Here we repo..View full abstract
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Awarded by National Health and Medical Research Council of Australia
We gratefully thank Drs. Audrey Ferrand and Oneel Patel for their stimulating discussions. This work is supported by grants 400062 (to GSB, AS), 208926 (to GB) and 350235 (to AS) from the National Health and Medical Research Council of Australia.