Journal article

Impact of clonal competition for peptide-MHC complexes on the CD8( ) T-cell repertoire selection in a persistent viral infection

Katherine K Wynn, Zara Fulton, Leanne Cooper, Sharon L Silins, Stephanie Gras, Julia K Archbold, Fleur E Tynan, John J Miles, James McCluskey, Scott R Burrows, Jamie Rossjohn, Rajiv Khanna

BLOOD | AMER SOC HEMATOLOGY | Published : 2008


CD8(+) T-cell responses to persistent viral infections are characterized by the accumulation of an oligoclonal T-cell repertoire and a reduction in the naive T-cell pool. However, the precise mechanism for this phenomenon remains elusive. Here we show that human cytomegalovirus (HCMV)-specific CD8(+) T cells recognizing distinct epitopes from the pp65 protein and restricted through an identical HLA class I allele (HLA B*3508) exhibited either a highly conserved public T-cell repertoire or a private, diverse T-cell response, which was uniquely altered in each donor following in vitro antigen exposure. Selection of a public T-cell receptor (TCR) was coincident with an atypical major histocompa..

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