Journal article

Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4

Julie M Fletcher, Margaret A Jordan, Sarah L Snelgrove, Robyn M Slattery, Francois D Dufour, Konstantinos Kyparissoudis, Gurdyal S Besra, Dale I Godfrey, Alan G Baxter

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2008

Abstract

Type 1 NKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. We have previously reported deficiencies in the numbers and function of NKT cells in the NOD mouse strain, which is a well-validated model of type 1 diabetes and systemic lupus erythematosus. Genetic control of thymic NKT cell numbers was mapped to two linkage regions: Nkt1 on distal chromosome 1 and Nkt2 on chromosome 2. Herein, we report the production and characterization of a NOD.Nkrp1(b).Nkt2b(b) congenic mouse strain, which has increased thymic and peripheral NKT cells, a decreased incidence of type 1 diabetes, and enhanced cytokine responses in vivo and increased pr..

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University of Melbourne Researchers

Grants

Awarded by Juvenile Diabetes Research Foundation


Awarded by MRC


Awarded by Medical Research Council


Funding Acknowledgements

A.G.B. and D.I.G. are supported by all Australian National Health and Medical Research Council (NHMRC) Research Fellowships. G.S.B. is the recipient of a Personal Research Chair front James Bardrick as a former Lister Institute-Jenner Research Fellow, J.M.F. is the recipient of an Australian Postgraduate Award, and M.A.J. and F.D.D. are recipients of James Cook University (JCU) intramural scholarships. This project was funded by the NHMRC, the Medical Genetics Research Advancement Program of JCU, the Medical Research Council (U.K.). The Wellcome Trust (U.K.). and Juvenile Diabetes Research Foundation Grant I-2003-244.