Journal article

Interrelationships between circulating gastrin and iron status in mice and humans

Suzana Kovac, Kelly Smith, Gregory J Anderson, John R Burgess, Arthur Shulkes, Graham S Baldwin

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2008

Abstract

The observations that the peptide hormone gastrin interacts with transferrin in vitro and that circulating gastrin concentrations are increased in the iron-loading disorder hemochromatosis suggest a possible link between gastrin and iron homeostasis. This study tested the hypothesis that gastrin and iron status are interrelated by measurement of iron homeostasis in mice and humans with abnormal circulating gastrin concentrations. Intestinal iron absorption was determined by (59)Fe uptake following oral gavage, and concentrations of duodenal divalent metal transporter-1 (DMT-1) and hepatic hepcidin mRNAs were determined by quantitative real-time PCR in agastrinemic (GasKO), hypergastrinemic c..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Institutes of Health


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia Grants 442913 ( to G. Anderson), 208926 and 400062 ( to G. Baldwin), and 350235 ( to A. Shulkes), Austin Hospital Medical Research Foundation Grants ( to G. Baldwin and A. Shulkes), and National Institutes of Health Grant GM065926 ( G. Anderson, G. Baldwin, and A. Shulkes).