Journal article

Oxcarbazepine, not its active metabolite, potentiates GABA(A) activation and aggravates absence seizures

Thomas Zheng, Alison L Clarke, Margaret J Morris, Christopher A Reid, Steven Petrou, Terence J O'Brien

Epilepsia | WILEY | Published : 2009


Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

The authors are grateful to Novartis Pharma AG, Basel, Switzerland, for the gift of the MHD, and to Dr. Markus Schmutz Ph.D., B.Sc., Novartis Distinguished Scientist, for his helpful comments on the manuscript. We also thank Chantel Trager and Dragica Maric for their technical help with the oocyte recordings. The study was supported by a Project grant from the Australian National Health and Medical Research Council to M.J.M., T.J.O., and C.A.R. (NH&MRC Project grant no. 400106), Novartis Pharma by the gift of drug (MHD), and an equipment loan from Compumedics, Melbourne, Australia.Conflict of interest: We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. T.J.O. has received support from Novartis Pharma Australia. None of the other authors have any conflicts of interest to disclose.