Journal article

Nephrogenic systemic fibrosis in a gadolinium-naive renal transplant recipient

Namrata S Anavekar, Alvin H Chong, Richard Norris, John Dowling, David Goodman

AUSTRALASIAN JOURNAL OF DERMATOLOGY | BLACKWELL PUBLISHING | Published : 2008

Abstract

A 36-year-old woman presented with a 2-year history of multiple, raised, brown papules and indurated skin over her lower legs. She had received a renal transplant 11 years earlier, and had a history of recurrent deep vein thromboses despite a negative thrombophilic screen. The patient had no history of exposure to gadolinium. Histology at this time revealed a light perivascular lymphoid infiltrate, activated fibroblasts and prominent capillary vessels. The patient re-presented 1 year later with persistence of these lesions, in the setting of worsening renal function requiring haemodialysis. Repeat skin biopsies demonstrated increased dermal collagen and angiogenesis. The dermatopathological ..

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