Journal article

Human parvovirus B19NS1 protein modulates inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cells

Anja Duechting, Carsten Tschoepe, Heike Kaiser, Tobias Lamkemeyer, Nobuyuki Tanaka, Susanne Aberle, Florian Lang, Joseph Torresi, Reinhard Kandolf, C-Thomas Bock

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2008

Abstract

The pathogenic mechanism by which parvovirus B19 may induce inflammatory cardiomyopathy (iCMP) is complex but is known to involve inflammatory processes, possibly including activation of JAK/STAT signaling. The nonstructural B19 protein NS1 acts as a transactivator triggering signaling cascades that eventually lead to activation of interleukin 6 (IL-6). We examined the impact of NS1 on modulation of STAT signaling in human endothelial cells (HMEC-1). The NS1 sequences were identified from B19 DNA isolated from the myocardia of patients with fatal iCMP. B19 infection as well as NS1 overexpression in HMEC-1 cells produced a significant upregulation in the phosphorylation of both tyrosine(705) ..

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University of Melbourne Researchers