The heritability of corneal hysteresis and ocular pulse amplitude - A twin study
Francis Carbonaro, Toby Andrew, David A Mackey, Tim D Spector, Chris J Hammond
OPHTHALMOLOGY | ELSEVIER SCIENCE INC | Published : 2008
PURPOSE: To examine the roles of genetic and environmental factors in corneal hysteresis and ocular pulse amplitude by performing a classic twin study. DESIGN: Cross-sectional twin study. PARTICIPANTS AND/OR CONTROLS: Two hundred sixty-four twin pairs: 135 monozygotic (MZ) and 129 dizygotic (DZ). METHODS: Corneal hysteresis was measured using the Reichert Ocular Response Analyzer (ORA; Reichert, Buffalo, NY), and ocular pulse amplitude was measured using the Pascal Dynamic Contour Tonometer (DCT; Swiss Microtechnology AG, Port, Switzerland). MAIN OUTCOME MEASURES: Contribution of genetic and environmental effects on corneal hysteresis and OPA among MZ and DZ twins. RESULTS: The mean corneal ..View full abstract
Supported by a grant from The Guide Dogs for The Blind Association, Berkshire, United Kingdom.