Risk factors for severe postoperative nausea and vomiting in a randomized trial of nitrous oxide-based vs nitrous oxide-free anaesthesia
K Leslie, PS Myles, MTV Chan, MJ Paech, P Peyton, A Forbes, D McKenzie
BRITISH JOURNAL OF ANAESTHESIA | OXFORD UNIV PRESS | Published : 2008
BACKGROUND: Refractory postoperative nausea and vomiting (PONV) requiring repeated treatment with antiemetic drugs is a miserable experience for the patient that may substantially increase the cost of care. As risk stratification may aid in prophylaxis and treatment, we explored risk factors for severe PONV in patients enrolled in a large international, randomized controlled trial (the ENIGMA trial). METHODS: Two thousand and fifty patients, aged > or =18 yr and undergoing surgery anticipated to exceed 2 h in duration, were recruited. Patients were randomized to nitrous oxide (N(2)O)-based or N(2)O-free anaesthesia. Choice of other anaesthetic, analgesic, and antiemetic drugs was left to the..View full abstract
Awarded by the Health and Health Services Research Fund
Supported by grants from the Australian National Health and Medical Research Council (the Australian National Health and Medical Research Council ), Canberra, Australia; the Australian and New Zealand College of Anaesthetists, Melbourne, Australia; and the Health and Health Services Research Fund (HHSRF 02030051), Hong Kong, People's Republic of China. P. S. M. is supported by an Australian National Health and Medical Research Council Practitioner's Fellowship. P. S. M. and A. F. are supported by the National Health and Medical Research Council Centre for Clinical Research Excellence in Therapeutics ( ID 219284). ClinicalTrials.gov identifier NCT00164047.