Journal article

Investigating if psychosis-like symptoms (PLIKS) are associated with family history of schizophrenia or paternal age in the ALSPAC birth cohort

Stanley Zammit, Jeremy Horwood, Andrew Thompson, Kate Thomas, Paulo Menezes, David Gunnel, Chris Hollis, Dieter Wolke, Glyn Lewis, Glynn Harrison

SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2008

Abstract

Psychosis-like symptoms (PLIKS) occur in about 15% of the population, but it is unclear to what extent PLIKS share aetiological mechanisms in common with those for schizophrenia. We examined whether the presence of PLIKS was associated with a family history of schizophrenia (FH-SCZ), or with advancing paternal age, using data from 6356 children in the ALSPAC birth cohort who participated in a semi-structured PLIKS interview at 12 years of age. We found no evidence of association between FH-SCZ and suspected or definite PLIKS (adjusted OR=0.94, 95%CI 0.44, 2.00; p=0.880). There was weak evidence that advancing paternal age was associated with increased PLIKS (adjusted OR per 10-year age incre..

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