Anatomical evidence for ileal Peyer's patches innervation by enteric nervous system: a potential route for prion neuroinvasion?
Roberto Chiocchetti, Gemma Mazzuoli, Valeria Albanese, Maurizio Mazzoni, Paolo Clavenzani, Giovanna Lalatta-Costerbosa, Maria L Lucchi, Giovanni Di Guardo, Giuseppe Marruchella, John B Furness
CELL AND TISSUE RESEARCH | SPRINGER | Published : 2008
We have examined the innervation of the gut-associated lymphoid system of the sheep ileum, with a view to identifying potential sites for neuroinvasion by pathogens, such as prions (PrP(Sc)). Special attention has been paid to the follicles of Peyer's patches (PPs), which are major sites of PrP(Sc) accumulation during infection. Evidence exists that the enteric nervous system, together with the parasympathetic and sympathetic pathways projecting to the intestine, are important for PrP(Sc) entry into the central nervous system. Thus, PrP(Sc) might move from PPs to the neurons and nerve fibres that innervate them. We investigated, by immunohistochemistry and retrograde tracing (DiI) from the f..View full abstract