Journal article
The Impact of Alcoholism on Sleep Evoked Delta Frequency Responses
Ian M Colrain, Kate E Crowley, Christian L Nicholas, Mayra Padilla, Fiona C Baker
BIOLOGICAL PSYCHIATRY | ELSEVIER SCIENCE INC | Published : 2009
Abstract
BACKGROUND: K-complexes (KCs) are evoked delta frequency electroencephalogram (EEG) responses during sleep that occur when large numbers of healthy cortical cells burst fire in a synchronized manner. The KC amplitude and incidence are sensitive measures of normal healthy brain aging. Given the known neurodegenerative consequences of alcohol abuse it was hypothesized that alcoholism would be associated with further KC amplitude and incidence reductions. METHODS: Eighty-four subjects (42 alcoholics) screened for medical, psychiatric, and sleep problems participated. The protocol involved the presentation of auditory stimuli during stage 2 sleep throughout a night in the laboratory. The KCs wer..
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Awarded by National Institutes of Health (National Institute on Alcohol Abuse and Alcoholism)
Funding Acknowledgements
The work was funded by National Institutes of Health (National Institute on Alcohol Abuse and Alcoholism) Grant AA14211. We wish to thank Dolf Pfefferbau, Edie Sullivan, and John Trinder for their contributions to the work.