Journal article

Neonate hippocampal volumes: Prematurity, perinatal predictors, and 2-year outcome

Deanne K Thompson, Stephen J Wood, Lex W Doyle, Simon K Warfield, Gregory A Lodygensky, Peter J Anderson, Gary F Egan, Terrie E Inder

ANNALS OF NEUROLOGY | WILEY-LISS | Published : 2008

Abstract

OBJECTIVE: To compare preterm (PT) and full-term (FT) infant hippocampal volumes and to investigate the relations among PT hippocampal volume, perinatal risk factors, and neurodevelopmental outcome. METHODS: A total of 184 PT and 32 full-term infants underwent magnetic resonance imaging at term equivalent age with manual segmentation of the hippocampi on coronal slices. Perinatal data were collected and 2-year neurodevelopment was evaluated with the Mental Development Index and Psychomotor Development Index on the Bayley Scales of Infant Development. RESULTS: PT and FT infant hippocampi did not significantly differ after controlling for head size, and percentage reductions in PT hippocampi (..

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Awarded by NCRR NIH HHS


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Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES