A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: Preliminary results

Abstract

PURPOSE: This prospective, randomized, controlled trial aims to provide evidence in relation to the efficacy and safety of corneal collagen cross-linking (CXL) in the management of progressive keratoconus. METHODS: Eligible eyes were separately randomized into either treatment or control groups. Collagen cross-linking was performed using 0.1% riboflavin (in 20% dextran T500) and ultraviolet A (UVA) irradiation (370 nm. 3 mW/cm2, 30 min) in accordance with a previously published protocol. At each review, a full clinical ophthalmic examination was performed including endothelial cell count and confocal microscopy. RESULTS: To date, 66 eyes of 49 patients with documented progression of keratoco..