Journal article

Randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: Preliminary results

Christine Wittig-Silva, Mark Whiting, Ecosse Lamoureux, Richard G Lindsay, Laurie J Sullivan, Grant R Snibson

JOURNAL OF REFRACTIVE SURGERY | SLACK INC | Published : 2008

Abstract

PURPOSE: This prospective, randomized, controlled trial aims to provide evidence in relation to the efficacy and safety of corneal collagen cross-linking (CXL) in the management of progressive keratoconus. METHODS: Eligible eyes were separately randomized into either treatment or control groups. Collagen crosslinking was performed using 0.1% riboflavin (in 20% dextran T500) and ultraviolet A (UVA) irradiation (370 nm, 3 mW/cm2, 30 min) in accordance with a previously published protocol. At each review, a full clinical ophthalmic examination was performed including endothelial cell count and confocal microscopy. RESULTS: To date, 66 eyes of 49 patients with documented progression of keratocon..

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