Journal article

Prevalence and risk factors of retinal arteriolar emboli: The Singapore Malay Eye Study

Ning Cheung, Lyndell Lim, Jie Jin Wang, FM Amirul Islam, Paul Mitchell, Seang Mei Saw, Tin Aung, Tien Y Wong

AMERICAN JOURNAL OF OPHTHALMOLOGY | ELSEVIER SCIENCE INC | Published : 2008

Abstract

PURPOSE: To examine the prevalence and risk factors of retinal arteriolar emboli, a risk predictor of stroke, in an Asian population. DESIGN: Population-based cross-sectional study. METHODS: Retinal emboli were ascertained from retinal photographs obtained from both eyes of 3,265 Asian Malays, aged 40 to 80 years, according to a standardized protocol. Risk factors were assessed from detailed standardized interviews, clinical examinations, and laboratory investigations. RESULTS: The overall prevalence of retinal emboli was 0.6% (95% confidence interval [CI], 0.58 to 0.62). A finding of retinal emboli was strongly associated with increasing age (P = .005, for trend), but age-stratified prevale..

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Grants

Awarded by NATIONAL MEDICAL RESEARCH COUNCIL


Awarded by Singapore and Biomedical Research Council, Singapore


Funding Acknowledgements

THIS STUDY WAS SUPPORTED BY THE NATIONAL MEDICAL RESEARCH COUNCIL GRANTS NOS. 0796/2003, 0863/2004, AND CSI/0002/2005, Singapore and Biomedical Research Council Grant 501/1/25-5, Singapore. Additional support was provided by the Singapore Tissue Network and the Ministry of Health, Singapore, Republic of Singapore. The authors indicate no financial conflict of interest. Involved in design and conduct of study (T.Y.W., S.M.S., T.A.); collection, management, analysis, and interpretation of the data (N.C., A.I., L.L., J.J.W., P.M.); and preparation, review, or approval of the manuscript (N.C., L.L., J.J.W., A.I., P.M., S.M.S., T.A., T.Y.W.). The Ethics Committee of the Singapore Eye Research Institute approved the study, and its conduct followed the tenets of the Declaration of Helsinki. Written informed consent was obtained from all parents after explaining the nature of the study. The authors thank the staff of the Singapore Malay Eye Study for their contribution in participant recruitment and data collection.