Journal article

Evidence of shared genes in refraction and axial length: The Genes in Myopia (GEM) twin study

Mohamed Dirani, Sri N Shekar, Paul N Baird

Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2008

Abstract

PURPOSE: Axial length has been shown to explain up to 50% of the total variance in refraction, with axial length and refraction having a major genetic component. However, no study has attempted to determine whether the correlation between axial length and refraction is explained by shared genetic or environmental factors. METHODS: All twins from Victoria aged 18 years or older were invited to participate in the Genes in Myopia (GEM) twin study through the Australian Twin Registry (ATR). Each twin completed a general questionnaire and underwent dilated objective refraction assessment and measurement of axial length. RESULTS: A total of 612 twin pairs (1224 twins) aged from 18 to 86 years were..

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