Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology
Kim L Bennell, Mark W Creaby, Tim V Wrigley, David J Hunter
ARTHRITIS AND RHEUMATISM | WILEY | Published : 2008
OBJECTIVE: Knee osteoarthritis (OA) is an organ-level failure of the joint involving pathologic changes in articular cartilage and bone. This cross-sectional study compared apparent volumetric bone mineral density (vBMD) of proximal tibial subchondral trabecular bone in people with and without knee OA, using peripheral quantitative computed tomography (pQCT). METHODS: Seventy-five individuals with mild or moderate medial compartment knee OA and 41 asymptomatic controls were recruited. Peripheral QCT was used to measure vBMD of trabecular bone beneath medial and lateral tibiofemoral compartments at levels of 2% and 4% of tibial length, distal to the tibial plateau. RESULTS: There was no signi..View full abstract
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Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
Supported by an Australian Research Council Large Infrastructure Equipment grant (LEO453623). a grant from the William Buckland Foundation (ANZ Trustees), and a National Health and Medical Research Council project grant (350297).