The evolution of the DLK1-DIO3 imprinted domain in mammals

CA Edwards; AJ Mungall; L Matthews; E Ryder; DJ Gray; AJ Pask; G Shaw; JAM Graves; J Rogers; I Dunham; MB Renfree; AC Ferguson-Smith; A Bateman; CK Chen; J Collins; J Gilbert; E Huckle; S Griffith-Jones; J Harrow; M Jones; M Larbaoui; K Oliver; C Scott; S Sims; C Steward; J Yang; G Smits; S Andrews; D Beury; C Krueger; E Ivanova; I McKendrick; P Smith; G Kelsey; W Reik

Journal article

The evolution of the DLK1-DIO3 imprinted domain in mammals

CA Edwards, AJ Mungall, L Matthews, E Ryder, DJ Gray, AJ Pask, G Shaw, JAM Graves, J Rogers, I Dunham, MB Renfree, AC Ferguson-Smith, A Bateman, CK Chen, J Collins, J Gilbert, E Huckle, S Griffith-Jones, J Harrow, M Jones Show all

Plos Biology | Published : 2008

DOI: 10.1371/journal.pbio.0060135

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Abstract

A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence analysis of the domain in se..

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