Using mammographic density to improve breast cancer screening outcomes
Anne M Kavanagh, Graham B Byrnes, Carolyn Nickson, Jennifer N Cawson, Graham G Giles, John L Hopper, Dorota M Gertig, Dallas R English
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | AMER ASSOC CANCER RESEARCH | Published : 2008
It is possible that the performance of mammographic screening would be improved if it is targeted at women at higher risk of breast cancer or who are more likely to have their cancer missed at screening, through more intensive screening or alternative screening modalities. We conducted a case-control study within a population-based Australian mammographic screening program (1,706 invasive breast cancers and 5,637 randomly selected controls). We used logistic regression to examine the effects of breast density, age, and hormone therapy use, all known to influence both breast cancer risk and the sensitivity of mammographic screening, on the risk of small (15 mm) screen-detected and interval br..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Grant support: This study was supported by the Victorian Health Promotion Foundation and the Department of Human Services Victoria, as well as National Health and Medical Research Council (NHMRC) Capacity Building Grant in Population Health Research 251533 (G.B. Byrnes), National Breast Cancer Foundation Ph.D. scholarship (C. Nickson), and NHMRC Australia Fellowship (J.L. Hopper).