Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders

Tsutomu Takahashi; Murat Yucel; Alison R Yung; Stephen J Wood; Lisa J Phillips; Gregor E Berger; Anthony Ang; Bridget Soulsby; Patrick D McGorry; Michio Suzuki; Dennis Velakoulis; Christos Pantelis

Journal article

Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders

Tsutomu Takahashi, Murat Yucel, Alison R Yung, Stephen J Wood, Lisa J Phillips, Gregor E Berger, Anthony Ang, Bridget Soulsby, Patrick D McGorry, Michio Suzuki, Dennis Velakoulis, Christos Pantelis

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2008

DOI: 10.1016/j.pnpbp.2008.07.007

Abstract

Abnormal neurodevelopment in midline structures such as the adhesio interthalamica (AI) has been reported in psychotic disorders, but it is unknown whether individuals at risk for the disorder share the AI findings observed in patients with florid psychosis. Magnetic resonance imaging of 162 patients with first-episode psychosis (FEP), 89 patients with chronic schizophrenia, 135 individuals at ultra high-risk (UHR) of psychosis (of whom 39 later developed psychosis), and 87 healthy controls were used to investigate the length and prevalence of the AI. The relation of the AI length to lateral ventricular enlargement was also explored. The patients with FEP and chronic schizophrenia as well as..

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University of Melbourne Researchers

Christos Pantelis Author Psychiatry

Stephen Wood Author Centre for Youth Mental Health

Patrick McGorry Author Centre for Youth Mental Health

Lisa Phillips Author Melbourne School of Psychological Sciences

Dennis Velakoulis Author Psychiatry

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Grants

Awarded by National Health & Medical Research Council (NHMRC)

Awarded by NHMRC

Awarded by NHMRC Clinical Career Development Award

Awarded by Japanese Society for the Promotion of Science

Awarded by Ministry of Health and Welfare, Japan

Funding Acknowledgements

This study was supported by project grants from the National Health & Medical Research Council (NHMRC; grant IDS: 145627, 145737, 970598, 981112, 970391), NHMRC Program Grant (ID: 350241), and the Colonial Foundation. Drs. Velakoulis and Wood were supported as Research Officers with funding from the NHMRC. Dr. McGorry was supported by a NARSAD Distinguished Investigator Award. Dr. Wood is currently supported by a Clinical Career Development Award from the NHMRC (ID: 359223) and a NARSAD Young Investigator Award. Dr. Yucel was supported by a NHMRC Clinical Career Development Award (ID: 509345). Dr. Takahashi was supported to undertake this work by a Grant-in-Aid for Scientific Research (No. 19591346) from the Japanese Society for the Promotion of Science, and a Research Grant (17-2,18-6) for Nervous and Mental Disorders from the Ministry of Health and Welfare, Japan. Dr. Takahashi was supported by a Program for Promoting Internationalization of University Education from the Ministry of Education, Culture, Sports, Science and Technology, Japan.