Insulin-like growth factors, their binding proteins, and prostate cancer risk: Analysis of individual patient data from 12 prospective studies
Andrew W Roddam, Naomi E Allen, Paul Appleby, Timothy J Key, Luigi Ferrucci, H Ballentine Carter, E Jeffrey Metter, Chu Chen, Noel S Weiss, Annette Fitzpatrick, Ann W Hsing, James V Lacey, Kathy Helzlsouer, Sabina Rinaldi, Elio Riboli, Rudolf Kaaks, Joop AMJL Janssen, Mark F Wildhagen, Fritz H Schroeder, Elizabeth A Platz Show all
ANNALS OF INTERNAL MEDICINE | AMER COLL PHYSICIANS | Published : 2008
BACKGROUND: Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer. PURPOSE: To assess the association between levels of IGFs and IGFBPs and the subsequent risk for prostate cancer. DATA SOURCES: Studies identified in PubMed, Web of Science, and CancerLit. STUDY SELECTION: The principal investigators of all studies that published data on circulating concentrations of sex steroids, IGFs, or IGFBPs and prostate cancer risk using prospectively collected blood samples were invited to collaborate. DATA EXTRACTION: Investigators provide..View full abstract
Awarded by NATIONAL INSTITUTE ON AGING
Awarded by Medical Research Council
The central pooling and analysis of these data were supported by Cancer Research UK, London, United Kingdom.