Journal article

Insulin-like growth factors, their binding proteins, and prostate cancer risk: Analysis of individual patient data from 12 prospective studies

Andrew W Roddam, Naomi E Allen, Paul Appleby, Timothy J Key, Luigi Ferrucci, H Ballentine Carter, E Jeffrey Metter, Chu Chen, Noel S Weiss, Annette Fitzpatrick, Ann W Hsing, James V Lacey, Kathy Helzlsouer, Sabina Rinaldi, Elio Riboli, Rudolf Kaaks, Joop AMJL Janssen, Mark F Wildhagen, Fritz H Schroeder, Elizabeth A Platz Show all

ANNALS OF INTERNAL MEDICINE | AMER COLL PHYSICIANS | Published : 2008

Abstract

BACKGROUND: Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer. PURPOSE: To assess the association between levels of IGFs and IGFBPs and the subsequent risk for prostate cancer. DATA SOURCES: Studies identified in PubMed, Web of Science, and CancerLit. STUDY SELECTION: The principal investigators of all studies that published data on circulating concentrations of sex steroids, IGFs, or IGFBPs and prostate cancer risk using prospectively collected blood samples were invited to collaborate. DATA EXTRACTION: Investigators provide..

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