Validation of "prodromal" criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up
Alison R Yung, Barnaby Nelson, Carrie Stanford, Magenta B Simmons, Elizabeth M Cosgrave, Eoin Killackey, Lisa J Phillips, Andreas Bechdolf, Joe Buckby, Patrick D McGorry
SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2008
BACKGROUND: Identification of individuals "prodromal" for schizophrenia and other psychotic disorders relies on criteria that predict onset within a brief period. Previous trials and biological research have been predicated on the view that certain "ultra high risk" (UHR) criteria detect "the prodrome", but there is a need to test the validity of these criteria. AIM: To assess the predictive validity of the UHR criteria in a clinical population. METHOD: The presence of UHR criteria was determined in 292 help-seeking individuals. At 2 year follow-up the number of new cases of psychotic disorder was assessed. RESULTS: The criteria significantly predicted onset of psychotic disorder within 2 ye..View full abstract
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Awarded by National Health and Medical Research (NHMRC) Program
All authors gratefully acknowledge the National Health and Medical Research (NHMRC) Program Grant (#350241) and the Colonial Foundation which provided funding for this study. We also thank the young people who participated.