Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination
Pavla Bojarova, Spencer J Williams
CURRENT OPINION IN CHEMICAL BIOLOGY | ELSEVIER SCI LTD | Published : 2008
Sulfotransferases and sulfatases are the major enzymes responsible for sulfate transfer processes. The past two years have seen the elucidation of new functions for these enzymes, and a great progression in their structural characterization, which confirms that these two types of enzymes possess a highly conserved fold. For catalytic activity, sulfatases must contain a formylglycine residue, which is generated by various formylglycine-generating enzymes. Mechanistic and structural details have recently been obtained for a group of cofactor-independent formylglycine-generating enzymes termed FGEs. Finally, an increasing light has been cast upon the mechanism of sulfatase inactivation by a gro..View full abstract
We thank the Australian Research Council for financial support.