What next for preimplantation genetic screening?
Joyce Harper, Karen Sermon, Joep Geraedts, Katerina Vesela, Gary Harton, Alan Thornhill, Tugce Pehlivan, Francesco Fiorentino, Sioban SenGupta, Christine de Die-Smulders, Cristina Magli, Celine Moutou, Leeanda Wilton
HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2008
Preimplantation genetic diagnosis for aneuploidy screening (preimplantation genetic screening-PGS) has been used to detect chromosomally normal embryos from subfertile patients. The main indications are advanced maternal age (AMA), repeated implantation failure, repeated miscarriages and severe male factor infertility. Many non-randomized PGS studies have been published and report an increase in implantation rate, and/or a decrease in miscarriage rate. Recently, two randomized controlled trials have been conducted on patients with AMA as the only indication. Neither study showed a benefit in performing PGS using live birth rate as the measure of success. The debate on the usefulness of PGS i..View full abstract