Journal article

Calreticulin in human pregnancy and pre-eclampsia

VY Gu, MH Wong, JL Stevenson, KE Crawford, SP Brennecke, NM Gude

MOLECULAR HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2008

Abstract

Pre-eclampsia is a disorder of human pregnancy that involves pregnancy-induced maternal hypertension and proteinuria. Evidence indicates that pre-eclampsia involves widespread activation of maternal endothelial cells. Calreticulin is a ubiquitously expressed, multi-functional protein that has been shown to have both pro- and anti-inflammatory effects on cultured endothelial cells in vitro and in whole animals. In order to clarify the role of this protein in normal human pregnancy and in pre-eclampsia, this study has measured expression of calreticulin in maternal blood and in placenta in patients with pre-eclampsia and in control pregnancies. There was a significant increase (approximately 5..

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