Journal article

Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus

Sreeja Sudhakaran, Craig R Rayner, Jian Li, David CM Kong, Neil M Gude, Roger L Nation

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | BLACKWELL PUBLISHING | Published : 2008

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: We have shown previously using the dually perfused isolated human placenta model that the maternal to foetal transfer of the antiviral protease inhibitor drug indinavir is substantially lower than the transfer in the opposite direction. This finding is not consistent with passive diffusion and indicates that a carrier-mediated mechanism is involved in retarding the movement in the maternal to foetal direction. The efflux transporter P-gp located in the apical membrane domain of the placental trophoblast cells has been implicated as the likely cause of the differential bi-directional transport. WHAT THIS STUDY ADDS: The present study also utilizes the..

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