Journal article

The Retinal Vasculature as a Fractal: Methodology, Reliability, and Relationship to Blood Pressure

Gerald Liew, Jie Jin Wang, Ning Cheung, Yong Ping Zhang, Wynne Hsu, Mong Li Lee, Paul Mitchell, Gabriella Tikellis, Bronwen Taylor, Tien Yin Wong



OBJECTIVE: Fractals represent a type of derived geometric pattern that permits the characterization of the branching pattern of retinal vessels. We examined a new semiautomated method to measure retinal vessel fractals. DESIGN: Methodology study. PARTICIPANTS: Three hundred randomly selected participants from the population-based Blue Mountains Eye Study. METHODS: We developed a semiautomated computer program to measure the fractal dimension (D(f)) of the retinal vessels from digitized images of disk-centered retinal photographs. Two trained graders masked to participant characteristics measured D(f) of right eye images of participants. Reliability was determined by repeat grading of the ima..

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Awarded by Australian National Health and Medical Research Council

Awarded by Singapore Bioimaging Consortium

Awarded by Biomedical Research Council

Funding Acknowledgements

Funded by the Australian National Health and Medical Research Council (Project grant IDs: 153948. 211069. and 302008) Singapore Bioimaging Consortium (R11 C-011/2006) and Biomedical Research Council (Grant No 501/1/25-5): Pfizer Australia (Cardiovascular Lipid Grant 2007): and Diabetes Australia Research Trust (Grant 2007).