Journal article

IS DEPRESSION ASSOCIATED WITH MICROVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES?

Tan Nguyen Thanh, Tien Y Wong, FM Amirul Islam, Larry Hubbard, Jacqueline Miller, Ebrahim Haroon, Christine Darwin, Barbara Esser, Anand Kumar

DEPRESSION AND ANXIETY | WILEY-BLACKWELL | Published : 2008

Abstract

We hypothesize that late-life depression is a manifestation of microvascular disease in patients with type 2 diabetes. We conducted a clinic-based cross-sectional study, comparing retinal vascular caliber, a marker of microvascular disease, in participants with type 2 diabetes with major depression (n=34), without depression (n=27) and healthy non-diabetic controls (n=38). Retinal vascular caliber was measured from digital retinal photographs using a validated computer-assisted method. After adjusting for age and gender, there was a trend of increasing retinal arteriolar caliber from healthy controls (132.6 microm), to diabetic patients without depression (139.2 microm), and diabetic patient..

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Grants

Awarded by National Institute of Health


Awarded by National Health and Medical Research Council, Australia


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

Contract grant sponsor: National Institute of Health; Contract grant numbers: R01-MH-63674, MH-55115, MH-61567, MH-02043; Contract grant sponsor: General Clinical Research Center; Contract grant sponsor: National Health and Medical Research Council, Australia; Contract grant numbers: 350448; Contract grant sponsor: Sylvia and Charles Viertel Clinical Investigator Award.