Electrophysiological evidence that drug cues have greater salience than other affective stimuli in opiate addiction
DI Lubman, NB Allen, LA Peters, JFW Deakin
JOURNAL OF PSYCHOPHARMACOLOGY | SAGE PUBLICATIONS LTD | Published : 2008
Previous research has demonstrated that drug cues are able to capture attentional resources in addicted populations. However, few studies have controlled for the possibility that drug users find all motivationally significant (i.e., affective) stimuli particularly salient. We examined this issue in opiate addiction, by exploring the impact of drug-related and affective stimuli on central attentional processes. Sixteen male heroin addicts (seven on opiate pharmacotherapy and nine recently detoxified subjects) and 12 matched controls were studied. Subjects were fitted with a 32-channel electrode cap and were instructed to passively view a series of neutral, affective and opiate-related images...View full abstract
DIL was supported by an MRC Training Fellowship. LAP was supported by a Wellcome Training Fellowship. The authors also wish to acknowledge the support of the Colonial Foundation.