Low pre-infection levels and loss of central memory CD4 T cells may predict rapid progression in SIV-infected pigtail macaques
Rosemarie D Mason, Robert De Rose, Nabila Seddiki, Anthony D Kelleher, Stephen J Kent
VIROLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008
CD4+ T lymphocyte subsets are targeted to different degrees by SIV infection. We studied central memory, effector memory, naïve, and regulatory T cell levels longitudinally in 11 SIV(mac251)-infected pigtail macaques. Depletion of CD28+CD95+ central memory CD4+ T cells, but not other populations, correlated with both SIV viral load and disease progression. A low pre-infection level of central memory CD4+ T cells was also predictive of rapid disease progression. If confirmed in larger studies, our results suggest stratifying macaques for baseline central memory CD4+ T cells would be useful in defining both the pathogenesis of SIV disease and SIV vaccine efficacy.
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Awarded by Australian National Health and Medical Research Council
Supported by the Australian Centre for HIV and Hepatitis Research, the Canadian Institutes of Health Research, and Australian National Health and Medical Research Council grants 299907, 251653, 454553, and 359281.