Compared to placebo, long-term antibiotics resolve otitis media with effusion (OME) and prevent acute otitis media with perforation (AOMwiP) in a high-risk population: A randomized controlled trial
Amanda J Leach, Peter S Morris, John D Mathews
BMC PEDIATRICS | BMC | Published : 2008
BACKGROUND: For children at high risk of chronic suppurative otitis media (CSOM), strategies to prevent acute otitis media with perforation (AOMwiP) may reduce progression to CSOM. METHODS: In a double blind study in northern Australia, 103 Aboriginal infants with first detection of OME were randomised to receive either amoxicillin (50 mg/kg/d BD) or placebo for 24 weeks, or until bilateral aerated middle ears were diagnosed at two successive monthly examinations (success). Standardised clinical assessments and international standards for microbiology were used. RESULTS: Five of 52 infants in the amoxicillin group and none of 51 infants in the placebo group achieved success at the end of the..View full abstract
Bev Hayhurst, Harold Koops, Angela Melder, Monica Pulakui and Liz Stubbs assisted with field data collection. Kim Hare, Jemima Beissbarth, Heidi Smith-Vaughan and Liz Stubbs assisted with laboratory work. Seija Leach, Robyn Liddle, Susan Donath, Susan Jacklyn and Joseph McDonnell assisted with data cleaning and analyses. Jo Bex, Sue Hutton and Abe Lukitch assisted with randomisation and blinding. The NHMRC and the Menzies School of Health Research funded the authors and these contributors.