Associations between fatty acids in colostrum and breast milk and risk of allergic disease
AJ Lowe, FCK Thien, RM Stoney, CM Bennett, CS Hosking, DJ Hill, JB Carlin, MJ Abramson, SC Dharmage
CLINICAL AND EXPERIMENTAL ALLERGY | WILEY-BLACKWELL | Published : 2008
BACKGROUND: Exposure to n-3 polyunsaturated fatty acids (PUFA) in early life is hypothesized to offer protection against atopic disease. However, there is controversy in this area, and we have previously observed that high levels of n-3 fatty acid (FA) in colostrum are associated with increased risk of allergic sensitization. OBJECTIVE: The aim of the study was to assess the relationship between FA profile in breast milk and risk of childhood atopic disease. METHODS: A high-risk birth cohort was recruited, and a total of 224 mothers provided a sample of colostrum (n=194) and/or 3-month expressed breast milk (n=118). FA concentrations were determined by gas chromatography. Presence of eczema,..View full abstract
We wish to thank Dr John Thorburn, FRACP, for assistance in patient recruitment and administrative assistance, the Mercy Hospital Department of Obstetrics for participant recruitment, Christine Axelrad for assistance with data collection, Anne Balloch for data management and Joan Raven and Judy Wicking for assistance with aliquoting the breast milk samples. We thank Mark Neumann, Child Nutrition Research Centre, Flinders Medical Centre, South Australia for performing the breast milk FA analysis.Initial development of MACS was supported by Nestle Australia. The assessment of FA profiles was supported by the Alfred Research Trusts. AJL is supported by Dairy Australia, CRC for Asthma and VicHealth. The Asthma Foundation of Victoria supported the 10-year follow-up. SCD is supported by the National Health and Medical Research Council. All authors of this manuscript declare that they have no competing interests.