Severe malaria in children and pregnancy: an update and perspective
Danny A Milner, Jacqui Montgomery, Karl B Seydel, Stephen J Rogerson
TRENDS IN PARASITOLOGY | ELSEVIER SCI LTD | Published : 2008
This review summarizes progress in preventing and treating severe malaria, which has been accompanied by advances in our understanding of the pathogenesis of severe malaria complications. New drugs such as intravenous artesunate and oral artemisinin combinations, with increased access to insecticide-treated bed nets, are improving outcomes and decreasing malaria deaths. Several groups are beginning to identify characteristics of parasite var genes associated with cerebral malaria. Understanding of the interactions between malaria and other diseases in causing severe anaemia and cerebral malaria has increased substantially, and at the cellular level, the disturbances leading to coma or other ..View full abstract
Awarded by National Institutes of Health
Awarded by Wellcome Trust
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We thank Terrie Taylor for permission to publish images from the Malawi autopsy Study and for ongoing support. D.M. is supported by award 5K23AI072033-02 from the National Institutes of Health. J.M. is Supported by a Research Career Development Fellowship from the Wellcome Trust (080964). S.J.R. is Supported by the National Health and Medical Research Council of Australia.