Journal article
The Apolipoprotein E ϵ4 Allele is not Associated With Cognitive Dysfunction in Cardiac Surgery
BS Silbert, LA Evered, DA Scott, TF Cowie
Annals of Thoracic Surgery | Published : 2008
Abstract
Background: The plasma protein apolipoprotein E (APOE) is a risk factor for degenerative cognitive decline manifested by mild cognitive impairment and later by Alzheimer's disease. Patients undergoing coronary artery bypass grafting (CABG) are known to have a high prevalence of preexisting cognitive impairment and postoperative cognitive dysfunction. Because both mild cognitive impairment and Alzheimer's disease generally occur in elderly individuals, the age group that commonly present for CABG, we investigated if the APOE ε{lunate}4 allele was associated with patients manifesting preexisting cognitive impairment and postoperative cognitive dysfunction. Methods: The DNA of 282 patients who ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council, Canberra, Australian Capital Territory, Australia (Project Grant #140510). We would like to thank Stavroula Kanellakis, BS, the Department of Pathology, University of Melbourne for helping with the genotyping.