Journal article
Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
J Fripp, P Bourgeat, O Acosta, P Raniga, M Modat, KE Pike, G Jones, G O'Keefe, CL Masters, D Ames, KA Ellis, P Maruff, J Currie, VL Villemagne, CC Rowe, O Salvado, S Ourselin
Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008
Abstract
β-amyloid (Aβ) deposition is one of the neuropathological hallmarks of Alzheimer's disease (AD), Aβ burden can be quantified using 11C PiB PET. Neuropathological studies have shown that the initial plaques are located in the temporal and orbitofrontal cortices, extending later to the cingulate, frontal and parietal cortices (Braak and Braak, 1997). Previous studies have shown an overlap in 11C PiB PET retention between AD, mild cognitive impairment (MCI) patients and normal elderly control (NC) participants. It has also been shown that there is a relationship between Aβ deposition and memory impairment in MCI patients. In this paper we explored the variability seen in 15 AD, 15 MCI and 18 NC..
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Funding Acknowledgements
This research was funded by the Commonwealth Scientific and Industrial Research Organisation (CSIRO) Preventative Health Flagship