Journal article

Appearance modeling of C-11 PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging

Jurgen Fripp, Pierrick Bourgeat, Oscar Acosta, Parnesh Raniga, Marc Modat, Kerryn E Pike, Gareth Jones, Graeme O'Keefe, Colin L Masters, David Ames, Kathryn A Ellis, Paul Maruff, Jon Currie, Victor L Villemagne, Christopher C Rowe, Olivier Salvado, Sebastien Ourselin

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008

Abstract

Beta-amyloid (Abeta) deposition is one of the neuropathological hallmarks of Alzheimer's disease (AD), Abeta burden can be quantified using (11)C PiB PET. Neuropathological studies have shown that the initial plaques are located in the temporal and orbitofrontal cortices, extending later to the cingulate, frontal and parietal cortices (Braak and Braak, 1997). Previous studies have shown an overlap in (11)C PiB PET retention between AD, mild cognitive impairment (MCI) patients and normal elderly control (NC) participants. It has also been shown that there is a relationship between Abeta deposition and memory impairment in MCI patients. In this paper we explored the variability seen in 15 AD, ..

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